Chlorpropamide

Indications & Dose:

Diabetes mellitus, type 2, neurogenic diabetes insipidus.

• BY MOUTH

Adults: PO 250 mg daily with breakfast. (elderly 100-125mg but avoid), adjusted according to response, max; 500mg daily

Children: Not recommended.

Contraindications:

Diabetes mellitus, type 1; ketoacidosis

Side Effects:

CNS: Dizziness, drowsiness, fatigue, headache, tinnitus, vertigo, weakness

GI: Anorexia, cholestatic jaundice, diarrhea, hepatotoxicity, hunger, nausea, vomiting

HEME: Agranulocytosis, aplastic anemia, hemolytic anemia, leukopenia, pancytopenia, thrombocytopenia

METAB: Hepatic porphyria, hypoglycemia, hyponatremia, syndrome of inappropriate antidiuretic hormone release

SKIN: Allergic reactions, eczema, erythema multiforme, exfoliative dermatitis,photo-sensitivity, pruritus, rash, urticaria

Cautions:

Precautions:

Elderly, cardiac disease, thyroid disease, renal disease, hepatic disease, severe hypoglycemic reactions

Interaction:

Anabolic steroids: Chlophenicol, Fibric acid derivatives,

MAOIs, Salicylates, Sulfonamides: Enhanced hypoglycemic effect

Ethanol: Altered glycemic control most commonly hypoglycemia; disulfiram-like reaction may occur

Halofenate: Increased sulfonylurea concentrations

NSAIDs: Enhanced hypoglycemic effect

Thiazide diuretics: Increased glucose concentrations, may increase dose requirements

Warnings:

Adverse Effects:

Lactations:

Inappropriate for use during pregnancy due to inadequate for blood glucose control, potential for prolonged neonatal hypoglycemia, and risk of congenital abnormalities; insulin is the drug of choice for control of blood sugars during pregnancy; breast milk reported at 17% of plasma; the potential for neonatal hypoglycemia dictates caution in nursing mothers

Old age: Use with caution.

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: