Doxazosin

Indications & Dose:

Hypertension

• BY MOUTH

Adult: Initially 1 mg once daily for 1–2 weeks, then increased to 2 mg once daily, then increased if necessary to 4 mg once daily; maximum 16 mg per day

Benign prostatic hyperplasia

• BY MOUTH

Adult: Initially 1 mg daily, dose may be doubled at intervals of 1–2 weeks according to response; usual maintenance 2–4 mg daily; maximum 8 mg per day 

Contraindications:

Age less than 1 month; cerebral edema; head injury; hypersensitivity to doxapram or its components; mechanical disorders of ventilation, including acute bronchial asthma, flail chest, muscle paresis, obstruction, pneumothorax, and pulmonary fibro-sis; pulmonary embolism; seizure disorder; severe cardiovascular disorder; severe hypertension; stroke; uncompensated heart failure 

Side Effects:

Posturnal hypotension (rarely associated with faintness) dizziness, vertigo, headache, fatigue, asthenia, oedema.

Cautions:

Precautions:

Interaction:

Drugs Clonidine:

Antihyperten-sive effect of clonidine may be decreased.

Beta-adrenergic blocking agents: May enhance ‘first dose’ acute postural hypo-tension of doxazosin.

Indomethacin: Antihypertensive effect of doxazosin decreased.

Verapamil & Nifedipine: Acute hypotensive effect when coadministered with prazosin.

Lab. Tests: False positive results may occur in screening tests for phaeochromocytoma in patients receiving prazosin. 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Disorientation, dizziness, headache
CV: Arrhythmias, including sinus tachycardia; hypertension
GI: Diarrhea, hiccups, nausea, vomiting
GU: Urine retention
RESP: Bronchospasm, cough, dyspnea
SKIN: Diaphoresis
Other: injection-site pain, redness, swelling, and thrombophlebitis. 

Patient And Carer Advice: