Nitrofurantion

Indications & Dose:

Urinary tract infection

• BY MOUTH

Adult

• PO 50-100 mg qid; 100 mg bid with food; for longterm suppressive therapy, 50-100 mg qhs Child >

1 mo

• PO 5-7 mg/kg/day divided qid x 1 week; for longterm suppressive therapy 1 mg/kg/day divided qdbid 

Contraindications:

CrCl < 60 ml/min (inadequate antibacterial concentrations achieved in urine), children < 1  mo, during labor and delivery (glutathione instability) 

Side Effects:

CNS: Asthenia, chills. conf usion, depression, dizziness, drowsiness, euphoria, headache, nystagmus, peripheral neuropathy (including optic neuritis), psychotic reactions (rare), vertigo

CV: ECG changes

GI: Abdominal pain, anorexia, cholestatic jaundice, chronic active hepatitis, diarrhea, hepatic necrosis, hepatitis, nausea, pancreatitis, parotitis, vomiting

GU: Superinfection of GU tract

HEME:Agranulocytosis, aplastic anemia, easinophilia, granulocytopenia, hemolytic anemia, leukopenia, megalablastic anemia, thrombocytopenia

MS: Arthralgia, myalgia

RESP: Acute and chronic pulmonary hypersensitivity reactions (dyspnea, chest pain, cough, pulmonary infiltration)

SKIN: Angioedema, erythema multiforme, exfoliative dermatitis, pruritus, rash, transient alopecia, urticaria

Cautions:

Precautions:

G-6-PD deficiency, renal impairment, anemia, diabetes, electrolyte imbalance, vitamin B deficiency, debilitating disease

Interaction:

Warnings:

Adverse Effects:

Lactations:

Pregnancy category B; compatible with breast feeding in infants > 1 mo

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: