Hydroxyprogesterone

Indications & Dose:

Amenorrhea (primary and secondary), dysfunctional uterine bleeding, metrorrhagia, metastatic endometrial carcinoma (palliative therapy). Threatened abortion, habitual abortion.
DOSAGE

Adult

Usual dose 250-500mg weekly during 1st half of the pregnancy.

Amenorrhea and uterine bleeding: IM 375 mg, repeated q4 wk prn

Endometrial carcinoma: IM 1-7 g/wk

Habitual abortion: After confirmation of pregnancy, 250-500mg IM at weekly intervals.

Threatened abortion: 500mg IM 2-3 times weekly. 

Contraindications:

Active thromboembolic disorders or thrombophlebitis, cerebral hemorrhage, impaired liver function or disease, breast cancer, undiagnosed vaginal bleeding, missed abortion, use as a diagnostic test for pregnancy 

Side Effects:

CNS: Depression, dizziness, fatigue, headache
CV: Edema
GI: Anorexia, cholestatic jaundice, increased weight, nausea, vomiting
GU: Amenorrhea, breakthrough bleeding, breast changes, dysmenorrhea, gynecomastia
METAB: Hyperglycemia
SKIN: Acne, alopecia, hirsutism, melasma, rash 

Cautions:

Precautions:

Epilepsy, migraine, asthma, cardiac or renal dysfunction, depression, diabetes

Interaction:

Drugs
Aminoglutethimide: Decreases progestin concentration 

Warnings:

Adverse Effects:

Lactations:

Pregnancy category D: an increased risk of hypospasdias in the male fetus and mild virilization of the female fetus have been reported with progestin use; progestins compatible with breast feeding 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: