Cyanocobalamin Vitamin B

Indications & Dose:

Vitamin B12 deficiency of dietary origin 

• BY MOUTH

Adult: 50–150 micrograms daily, dose to be taken between meals

• BY INTRAMUSCULAR INJECTION

Adult: Initially 1 mg every 2–3 days for 11 doses; maintenance 1 mg every month 

Contraindications:

 Hypersensitivity to the component.

Side Effects:

Pruritis, urticaria, weakness, sweating, nausea, abdominal pain, diarrohea, G. I. diseases, restlessness, tightness of throat, angioneurotic oedema, cyanosis pulmonary edema, Activation of peptic ulcer, jaundice, flushing, skin rash, dryness of skin, itching,  hypotention, transient headache, allergy. 

Cautions:

In gallbladder diseases, peptic ulcer, glaucoma, elevated uric acid, liver diseases. 

Precautions:

Interaction:

Drug-drug.

Aminoglycosides, aminosalicylic acid and its salts, anticonvulsants, cobalt irradiation of the small bowel, colchicine, extendedrelease potassium preparations: May decrease vitamin B12 absorption from GI tract. Don’t use together. Ascorbic acid: May destroy vitamin B12. Don’t give within 1 hour of vitamin B12.

Chloramphenicol: May antagonize hematopoietic response. Don’t give together.

Colchicine: May increase neomycin-induced malabsorption of vitamin B12. Don’t use together. 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CV: heart failure, peripheral vascular thrombosis.

GI: transient diarrhea.

Respiratory: pulmonary edema.

Skin: itching, transitory exanthema, urticaria; pain and burning at S.C. or I.M. injection site.

Other: anaphylaxis with parenteral use. Effects on lab test results

•   May cause false-positive results for intrinsic factor antibodies, which are present in the blood of half of all patients with pernicious anemia. 

Patient And Carer Advice: