Desferoxamine Mesylate

Indications & Dose:

Adult

• Acute iron intoxication:


• BY INJECTION

IM 1 g stat, then 0.5 g q4h for 2 doses, additional doses of 0.5 gq4-l 2h prn, max 6 g/day; IV infuse at a rate < l5 mg/kg/hr, dosage the same as TM max 6 g/day (use only in cardiovascular collapse)

• Chronic iron overload: 

• BY INJECTION

TM 0.5-I g/day; SC via portable pump INF 1-2 g/ day over 8-12 hr; IV give 2 g with, but separate from, each unit of blood at a rate < 15 mg/kg/hr

Child

•  Acute iron intoxication:

• BY INJECTION

IM 90 mg/kg q8h, max 6 g/day; IV 15 mg/kg/hr, max 6 g/day 

Chronic iron overload:

• BY INJECTION

IV 15 mg/kg/hr, max 6 g/day; SC via portable pump INF 20-40 mg/kg/day over 8-12 hr 

Contraindications:

Severe renal disease or anuria 

Side Effects:

CV: Hypotension (with rapid IV inj), tachycardia
GI: Abdominal cramps, diarrhea
EENT: Blurred vision, cataracts, ototoxicity
MS: Leg cramps
SKIN: Erythema, pain at inj site, proritus, urticaria 

Cautions:

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Pregnancy category C; excretion into breast milk unknown; use caution in nursing mothers

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: