Vitamin D Cholecalciferol (Vitamin D3)

Indications & Dose:

Dietary supplement, vitamin D deficiency, refractory rickets, renal osteodystrophy, hypoparathyroidism, hypophosphatemia, hypocalcemic tetany, osteoporosis

BY INJECTION

Rickets:

1 ampoule of  200000 i.u of D3 every six months or 2 ampoules of  400000 i.u every six months if child is rarely exposed to sun or heavily pigmented.

Osteomalacia:

Same as rickets.

Orally or IM inj: Adult  ; 10mg twice a year (5mg per dose)

Antenatal prophylaxis:

1 ampoule of  at the start of 7th month of pregnancy.

Lactation

ampoule of  at the start of breast feedign taking into accoutn any previous administration with a minimum interval of 4 months.

Prevention of vitamin D deficiency 

•  BY MOUTH

Adult: 400 units daily

Treatment of vitamin D deficiency 

• BY MOUTH

Adult: 800 units daily, higher doses may be necessary for severe deficiency 

Contraindications:

Hypercalcemia, renal dysfunction, hyperphosphatemia, abnormal sensitivity ‘to the toxic effects of vitamin D and hypervitaminosis D 

Side Effects:

CNS: Drowsiness, fatigue, headache, psychosis, seizures, weakness, anorexia
CV: Dysrhythmias, hypertension, vascular calcification
GI: Constipation, cramps, diarrhea, dry mouth, metallic taste, nausea, vomiting, pancreatitis, elevated ALT/AST
GU: Albuminuria, decreased libido, hematuria, nocturia, polyuria, reversible azotemia
METAB: Hypercholesterolemia, mild acidosis
MS: Bone pain; muscle pain, weakness
SKIN: Photopfiobia, pruritus 
MISC: Weight, loss 

Cautions:

Precautions:

Cardiovascular disease, renal calculi, elderly 

Interaction:

Labs
Interference: Serum cholesterol 

Warnings:

Adverse Effects:

Lactations:

(400 IU/d); (doses above recommended daily allowance) associated with supravalvular aortic stenosis, elfin facies, and mental retardation; caution should be exercised when ergocalciferol is administered to nursing women; vitamin D and metabolites appear in breast milk; compatible with breast feeding, but infant should be monitored for hypercalcemia if doses exceed recommended daily allowance

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: