Indications & Dose:
Patients with severe renal impairment requiring vitamin D therapy
Adult: Initially 1 microgram daily, dose to be adjusted to avoid hypercalcaemia; maintenance 0.25–1 microgram daily
Elderly: Initially 500 nanograms daily, dose adjusted to avoid hypercalcaemia; maintenance 0.25–1 microgram daily
Hypophosphataemic rickets | Persistent hypocalcaemia due to hypoparathyroidism or pseudohypoparathyroidism
Child 1 month–11 years: 25–50 nanograms/kg once daily, dose to be adjusted as necessary; maximum 1 microgram per day
Child 12–17 years: 1 microgram once daily, dose to be adjusted as necessary
Prevention of vitamin D deficiency in renal or cholestatic liver disease
Child 1 month–11 years (body-weight up to 20 kg): 15–30 nanograms/kg once daily (max. per dose 500 nanograms) Child 1 month–11 years (body-weight 20 kg and above): 250–500 nanograms once daily, dose to be adjusted as necessary
Child 12–17 years: 250–500 nanograms once daily, dose to be adjusted as necessary
Contraindications:
Hyperphosphataemia (except when occurring with hypoparathyroidism),hypercalcaemia, vitamin D toxicity
Side Effects:
Hypercalcaemia and hyperphosphataemia.
Cautions:
Precautions:
Hypercalciuria, renal impairment.
Pregnancy, breast-feeding & old age: Use with caution.
Interaction:
Drugs
Digitalis Preparations: Cardiac arrhythmias precipitated.
Thiazide Diuretics: Hypercalcaemic response enhanced.
Barbiturates and other enzyme inducing anticonvulsants: Reduce efficacy.
Mineral oil: Prolonged use reduces efficacy.
Cholestyramine, Cholestipol, Sucralfate, Aluminium based Antaicds: Reduce efficacy – by decreasing absorption of alfacalcidol.
Magnesium based Antaicds or Laxatives: Hypermagnesaemia in those on chronic renal dialysis.
Warnings:
Adverse Effects:
Lactations:
Special Precautions:
Counselling:
Side Effects Or Adverse Reactions:
Patient And Carer Advice:
© Pakistan Drug Directory. All Rights Reserved.
Designed By: Pakistan Drug Directory Team