(Tocopheryl acetate)

Indications & Dose:

Adults:
Nocturnal muscle cramps:   
BY MOUTH
400mg daily for 8-12 weeks. Intermittent
claudication:  BY MOUTH 400mg daily for 12-18 weeks. Fibrocystic breast disease:
BY MOUTH 600mg daily for 2-6 months. CAD: BY MOUTH 100-200mg daily for at least 2 years.
Children: 200mg daily. Vitamin E deficiency in cholestasis and severe liver disease
BY MOUTH
Child 1 month–11
years: Initially 100 mg daily, adjusted according to response, increased if necessary up to 200 mg/kg daily Child 12–17 years: Initially 200 mg daily, adjusted according to response, increased if necessary up to 200 mg/kg daily
Malabsorption in abetalipoproteinaemia
BY MOUTH
Adult: 50–100 mg/kg once daily 

Contraindications:

Side Effects:

CNS: Fatigue. headache
EENT: Blurred vision
GI: Cramps, diarrhea, nausea
GU: Gonadal dysfunction
METAB: Altered metabolism of thyroid, pituitary, and adrenal hormones
MS: Weakness
SKIN: Contact dermatitis, sterile abscess 

Cautions:

Precautions:

Interaction:

Drugs
Iron: Impaired hematological response to iron in children with irondeficiency anemia Oral
anticoagulants: Vitamin E increases hypoprathombinemic response to oral anticoagulants, especially in doses >400 IU/day 

Warnings:

Adverse Effects:

Lactations:

If used above recommended daily allowance doses); recommended daily allowance in pregnancy is 15 IU; excreted into breast milk, 5 times richer in vitamin E than cow’s milk; U.S. recommended daily allowance of vitamin E during lactation is 16 IU 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: