Orphenadrine

Indications & Dose:

Musculo-skeletal disorders, traumas, sports injuries, low backache. Tension, headache. Sprains and strains. Parkinsonism, including the drug induced.
Adults: Initially

• BY MOUTH

50mg thrice daily increasing by 50mg every 2-3 days. Maint: usually 100-300mg daily. Max: 400mg daily.

• BY INJECTION

40mg  three times daily

Children: Not recommended. 

Contraindications:

Prostate hypertrophy, myasthenia gravis, narrow angle glaucoma, tardive dyskinesia. Hypersensitivity. 

Side Effects:

Cautions:

Precautions:

Urinary retention, impaired hepatic or renal function. Tachycardia, GI obstruction. Caution while driving or operating machinery.

Pregnancy: Safety not established.

Breastfeeding: Use with caution.

Old age: Use with caution. 

Interaction:

Drugs
Anticholinergics,MAOIs, and Anti-depressants: Effects of these agents potentiated.

Propoxyphene: Confusion, anxiety and tremors.

Chlorpromazine: Therapeutic effects of chlorpromazine may be decreased.

Haloperidol: Worsening of schizophrenic symptoms, decreased haloperidol levels and development of tardive dyskinesias.

Levodopa:  Synergistic effect.

Barbiturates, steroids and phenylbutazone: Orphenadrine antagonises effects of these drugs. 

Warnings:

Adverse Effects:

Dry mouth, blurred vision, nausea, dizziness, restlessness

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: