Aceclofenac

Indications & Dose:

Pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Conditions involving dental & gynaecological pain  Symptomatic treatment of pain and inflammation in post traumatic pain, cervical pain, lowback pain, migraine.
Adult

• BY MOUTH:

Maximum recommended dose is 200mg taken as preparation of 100mg bid, before or after meal.

Child Not recommended.

• BY INJECTION:

Maximum recommended dose is 200mg taken as preparation of 100mg bid, before or after meal.

Child  Not recommended. 

Contraindications:

Active gastro-intestinal bleeding . active gastro-intestinal ulceration . cerebrovascular disease . history of gastro-intestinal bleeding related to previous NSAID therapy . history of gastro-intestinal perforation related to previous NSAID therapy . history of recurrent gastro-intestinal haemorrhage (two or more distinct episodes) . history of recurrent gastro-intestinal ulceration (two or more distinct episodes) . ischaemic heart disease . mild heart failure . peripheral arterial disease . severe heart failure 

Side Effects:

Rare Alveolitis . aseptic meningitis (patients with connective-tissue disorders such as systemic lupus erythematosus may be especially susceptible) . hepatic damage . interstitial fibrosis associated with NSAIDs can lead to renal failure . pancreatitis . papillary necrosis associated with NSAIDs can lead to renal failure . pulmonary eosinophilia . Stevens-Johnson syndrome . toxic epidermal necrolysis . visual disturbances Frequency not known Angioedema . blood disorders . bronchospasm . colitis (induction of or exacerbation of) . Crohn’s disease (induction of or exacerbation of) . depression . diarrhoea . dizziness . drowsiness . fluid retention (rarely precipitating congestive heart failure) . gastrointestinal bleeding . gastro-intestinal discomfort . gastro-intestinal disturbances . gastro-intestinal ulceration . haematuria . headache . hearing disturbances . hypersensitivity reactions . insomnia . nausea . nervousness . photosensitivity . raised blood pressure . rashes . renal failure (especially in patients with preexisting renal impairment) . tinnitus . vertigo.

PREGNANCY Most manufacturers advise avoiding the use of NSAIDs during pregnancy

BREAST FEEDING Use with caution during breast-feeding.

HEPATIC IMPAIRMENT Initially 100mg daily. Use with caution; there is an increased risk of gastrointestinal bleeding and fluid retention. Avoid in severe liver disease.

RENAL IMPAIRMENT The lowest effective dose should be used for the shortest possible duration. Avoid if possible or use with caution; avoid in moderate to severe impairment. In renal impairment monitor renal function; sodium and water retention may occur and renal function may deteriorate, possibly leading to renal failure.

Cautions:

Allergic disorders . avoid in acute porphyrias . cardiac impairment (NSAIDs may impair renal function) . coagulation defects . connective-tissue disorders . Crohn’s disease (may be exacerbated) . elderly (risk of serious sideeffects and fatalities) . history of cardiac failure . hypertension . left ventricular dysfunction . oedema . risk factors for cardiovascular events . ulcerative colitis (may be exacerbated) 

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: