Celecoxib

Indications & Dose:

Adult and Child >16yr

Osteoarthritis

• BY MOUTH

PO 200 mg qd or 100 mg bid

Rheumatoid arthritis:

• BY MOUTH

PO 100-200 mg bid

Acute pain and primary dysmenorrhea

• BY MOUTH

400 mg initially, additional 200 mg  on first day, 200 mg bid on subsequent days

Familial adenomatosis polyposis:

• BY MOUTH

400 in mg bid with food 

Contraindications:

Documents at allergictype reaction to suIfonamides, rhinitis, urticaria. asthma, or allergic reactions to aspirin or other antiinflammatory agents 

Side Effects:

Cautions:

Precautions:

Late pregnancy (premature Closure of ductus arteriosus), liver dysfunction, hypertension, congestive heart failure, previous history of gastrointestinal ulceration, bleeding, or perforation, renal dysfunction, concurrent use of’ warfarin 

Interaction:

Drugs
Diuretics: Potential reduction of both diuretic and antihypertensive effects of loop and thiazide diuretics 9

ACE-inhibitors: May reduce antihypertensive effect of ACE-inhibitors

Fluconazole: Two-fold increase in celecoxib plasma concentration due to inhibition of CYP2C93
Lithium: Steady-state lithium plasma levels increased 18% El
Warfarin: Bleeding events reported predominantly in elderly; increases in PT possible

Warnings:

Adverse Effects:

Lactations:

Pregnancy category C milk  secretion, unknown

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Dizziness, headache
CV Fluid retention. peripheral edema FENT Hypersensitivity reactions in aspirin-sensitive asthma patients
GI: Dyspepsia, diarrhea, abdominal pain, flatulence, Ulcer, gastroint tinal bleed, LFT elevations
GU: Acute renal failure
RESP: Upper respiratory tract in eciion, sinusitis, pharyngitis, rhinitis 

Patient And Carer Advice: