Dexibuprofen

Indications & Dose:

Osteoarthritis including dental pain

• BY MOUTH

300mg Tablets:  The usual dose is 300mg tablet 2 to 3 times a day. For acute symptoms, the dose may be increased to 300mg tablet 4 times a day

400mg Tablets: The usual dose is 400mg tablet 2 times a day. For acute symptoms, the dose may be increased to 400mg tablet 3 times a day

For period (menstrual) pain

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The usual dose is 300mg tablet 2 to 3 times a day The usual dose is 400mg tablet 2 times a day

For mild to moderate pain

• BY MOUTH

The usual dose is 300mg tablet 2 times a day. If needed the dose may be increased to 300mg tablet 4 times a day The usual dose is 200mg tablet 3 times a day. If needed the dose may be increased to 400mg tablet 3 times a day

HEPATIC DYSFUNCTION: Patients with mild to moderate hepatic dysfunction should start therapy at reduced doses and be closely monitored. Dexibuprofen should not be used in patients with severe hepatic dysfunction

RENAL DYSFUNCTION: The initial dosage should be reduced in patients with mild to moderate impaired renal function. Dexibuprofen should not be used in patients with severe renal dysfunction

CHILDREN AND ADOLESCENTS: Should not be used below the age of 18 

Contraindications:

Patients with hypersensitivity to dexibuprofen or other nonsteroidal anti-inflammatory drugs

• Patients with active or suspected gastrointestinal ulcer or history of recurrent gastrointestinal ulcer

• Patients who have gastrointestinal bleeding or other active bleedings or bleeding disorders

• Patients with active Crohn’s disease or active ulcetative colitis

• Patients with severe renal dysfunction (GFR < 30ml/min)

• Patients with severely impaired hepatic function

• Patients with haemorrhagic diathesis and other coagulation disorders, or patients receiving anticoagulant therapy

• From the beginning of 6th month of pregnancy 

Side Effects:

The most common adverse events are gastrointestinal in nature 

Cautions:

Precautions:

Symptoms or history of gastrointestinal disease, asthma, impaired hepatic, cardiac or renal function. NSA1D may mask infections or temporarily inhibit platelet aggregation. In late pregnancy, as with other NSAIDs, it should be avoided as it may cause premature closure of ductus arteriosus. Dexibuprofen should be used with caution in nursing mothers 

Interaction:

Anticoagulants: The effects of anticoagulants on bleeding time can be potentiated by NSAIDs. If concomitant treatment can not be avoided blood coagulation tests (INR, bleeding time) should be performed during the initiation of dexibuprofen treatment and the dosage of the anticoagulant should be adjusted if necessary

Methotrexate used at doses of 15 mg/week or more: If NSAIDs and methotrexate are given within 24 hours of each other plasma levels of methotrexate may increase, via a reduction in its renal clearance thus increasing the potential for methotrexate toxicity. Therefore, in patients receiving high-dose treatment with methotrexate, the concomitant use of dexibuprofen is not recommended

Lithium: NSAIDs can increase the plasma levels of lithium, by reducing its renal clearance. The combination is not recommended. Frequent lithium monitoring should be performed. The possibility of reducing the dose of lithium should be considered Other NSAIDs and salicylates (acetylsalicylic acid at doses above those used for anti-thrombotic treatment, approximately 100 mg/day ): The concomitant use with other NSAIDs should be avoided, since simultaneous administration of different NSAIDs can increase the risk of gastrointestinal ulceration and hemorrhage

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: