Indications & Dose:
Susceptible infections due to sensitive Grampositive and Gram-negative bacteria
Child 1–11 months: 20 mg/kg daily in 3 divided doses, alternatively 62.5 mg 3 times a day
Child 1–4 years: 20 mg/kg daily in 3 divided doses, alternatively 125 mg 3 times a day
Child 5–11 years: 20 mg/kg daily in 3 divided doses, usual max. 1 g daily, alternatively 250 mg 3 times a day
Child 12–17 years: 250 mg 3 times a day; maximum 4 g per day
Adult: 250 mg 3 times a day; maximum 4 g per day
Child 12–17 years: 375 mg every 12 hours, dose to be taken with food
Adult: 375 mg every 12 hours, dose to be taken with food
Severe susceptible infections due to sensitive Grampositive and Gram-negative bacteria
Child 1–11 months: 40 mg/kg daily in 3 divided doses, usual max. 1 g daily, alternatively 125 mg 3 times a day
Child 1–4 years: 40 mg/kg daily in 3 divided doses, usual max. 1 g daily, alternatively 250 mg 3 times a day
Child 5–11 years: 40 mg/kg daily in 3 divided doses, usual max. 1 g daily
Child 12–17 years: 500 mg 3 times a day; maximum 4 g per day
Adult: 500 mg 3 times a day; maximum 4 g per day
Pneumonia
Child 12–17 years: 750 mg every 12 hours, dose to be taken with food
Adult: 750 mg every 12 hours, dose to be taken with food Lower urinary-tract infections
Child 12–17 years: 375 mg every 12 hours, dose to be taken with food Adult: 375 mg every 12 hours, dose to be taken with food
Asymptomatic carriage of Haemophilus influenzae or mild exacerbations in cystic fibrosis
Child 1–11 months: 125 mg every 8 hours
Child 1–6 years: 250 mg 3 times a day
Child 7–17 years: 500 mg 3 times a day
Contraindications:
Infants < 1 month
Side Effects:
Cautions:
Precautions:
Interaction:
Drugs
Aminoglycosides: Additive nephrotoxicity
Loop diuretics: Increased nephrotoxicity
Warfarin: Hypoprothrombinemic response enhanced
Warnings:
Adverse Effects:
Lactations:
Special Precautions:
Counselling:
Side Effects Or Adverse Reactions:
CNS: Chills, dizziness, fever, headache, paresthesia, weakness
GI: Abdominal pain, anorexia, bleeding, diarrhea, glossitis, increased LFTs, nausea, pseudomembranous colitis, vomiting
GU: Candidiasis, nephrotoxicity, vaginitis
HEME: Bone marrow suppression eosinophilia, hemolytic anemia, lymphocytosis, thrombocytosis
RESP: Dyspnea
SKIN: Dermatitis, rash, urticaria
MISC.: Serum sickness-like syndrome
PREGNANCY Not known to be harmful.
BREAST FEEDING Present in milk in low concentration, but appropriate to use.
RENAL IMPAIRMENT No dose adjustment required. Manufacturer advises caution.
Patient And Carer Advice:
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