Basiliximab

Indications & Dose:

Prophylaxis of acute rejection in allogeneic renal transplantation used in combination with ciclosporin and corticosteroid-containing immunosuppression regimens (specialist use only) 

• BY INTRAVENOUS INJECTION, OR BY

INTRAVENOUS INFUSION

Adult: Initially 20 mg, administered within 2 hours before transplant surgery, followed by 20 mg after 4 days, dose to be administered after surgery, withhold second dose if severe hypersensitivity or graft loss occurs 

Contraindications:

Known hypersensitivity to basiliximab or any other component of the formulation.
Children

In pediatric patients : i.v. infusion over 20-30 minutes or as a bolus injection. Weighing less than 40kg, 20mg given in 2 doses of 10mg each. 40kg or more; 40mg given in 2 doses of 20mg each.

Elderly Same as adult dose

Side Effects:

Urinary tract infection, pain, nausea, peripheral edema, hypertension, 94 patients receiving the recommended dose in uncontrolled trials. 

Cautions:

Precautions:

Should be prescribed only by physicians who are experienced in the use of immuno-suppressive therapy following organ transplantation.

Interaction:

Drugs
No metabolic drug-drug interactions are to be expected. 

Warnings:

Adverse Effects:

Lactations:

Should not be given to pregnant or lactating women. except in cases where the potential benefit for the mother outweighs the potential risk for the fetus. following the 2nd dose

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: