Mercaptopurine

Indications & Dose:

In combination therapy scedules for acute leukaemia, choriocarcinoma, chronic granulocytic leukaemia.
DOSE

Adult and children

Usually 2.5mg/kg body weight daily

Contraindications:

Side Effects:

Nausea, vomiting, diarrhoea, cholestasis, bone marrow depression, pancreatitis, oral and intestinal ulcers. Rarely hepatic necrosis. 

Cautions:

Precautions:

Impaired renal and hepatic function, monitor uric acid level, blood counts and hepatic functions 

Interaction:

Drugs
Allopurinol; Delayed catabolism of mercapturine resulting in severe toxicity. Dose of mercapturine should be reduced to one third to one-quarter of usual dose

Other mylosuppresive agents; Enhance antineoplastic effect of mercapturine

Sulphonamides; May result in enhancd bone marrow depression 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: