Miconazole Nitrate

Indications & Dose:

Fungal infection of oropharyn-geal cavity & G. I. tract.

DOSE

Local applications 2-3 times daily

Contraindications:

Side Effects:

Cautions:

Precautions:

Renal disease, hepatic disease

Interaction:

Drugs
 

• The base in suppository products may interfere with latex; do not use these with contraceptive diaphragms, condoms

Drugs

Aminogl ycosides: Decreased antibiotic peak levels

Astemizole: QT prolongation and arrhythmia

Cisapride: Increased cisapride concentrations, toxicity and arrhythrnias

Coumarin drugs: Enhanced anticoagulant effect

Cyclosporine: Possible increased cyclosporine levels

Felodipine: Enhanced vasodilation, hypotension

HMG-CoA reductase inhihitors (e.g. lavastatin): Increased toxicity, rhabdomyolysis

Loratadine: Increased loratadine concentrations

Midazolam: Reduced midazolam metabolism

Quinidine: Increased quinidine concentrations

Tacrolimus: Possible increased tacrolimus levels

Tolbutamide: Inhibition of tolbutamide metabolism

Triazolam: Reduced triazolam metabolism

Warfarin: Enhanced anticoagulant effect 

Warnings:

Adverse Effects:

Lactations:

Pregnancy category C (Top category B); unknown if excreted into breast milk

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Drowsiness, headache 
CV: Dysrhythmias (rapid IV), tachycardia
GI: Anorexia, cramps, diarrhea, nausea, vomiting (IV)
GU: Hyponatremia, itching, pelvic cramps (topical forms), vulvovaginal burning
HEME: Thrombocytapenia
METAB: Hyperlipidemia (due to vehicle in IV prep)
SKIN: Fever, flushing, hives, phlebitis (IV), pruritus, rash 

Patient And Carer Advice: