Clinical Pharmacology Details


Polio Vaccine


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Indications & Dose:


Infants and children (primary series): TThe dose of OPV is 2-3 drops being dropped directly into the mouth of the child.


DOSAGE:


As per guideline of WHO or refer to manfufacturer.

Contraindications:

Contraindicated in patients hypersensitive to the vaccine or any of its components, including phenoxyethanol, formaldehyde, neomycin, streptomycin, or polymyxin B. A history of delayedtype hypersensitivity reaction to neomycin is generally not a contraindication.


Use cautiously in siblings of children with immunodeficiency syndrome.

Side Effects:

Cautions:

Precautions:

Interaction:

Drug-drug. Immune serum globulin, transfusions of blood or blood products: May interfere with immune response to vaccine. Defer vaccination for 3 months


Chemotherapeutic drugs, immunosuppressants (alkylating agents, antimetabolites, steroids), radiation treatment: May decrease immunologic response to IPV. Defer IPV until other therapy stops. If patient receives IPV within 2 weeks before receiving chemotherapy or radiation, consider the patient unimmunized and re-vaccinate at least 3 months after chemotherapy or radiation stops.

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: fever, sleepiness.
GI: decreased appetite
Skin: erythema, induration, pain (at injection site).
Other: crying, hypersensitivity reactions, poliomyelitis.

Patient And Carer Advice: