RHO Immunoglobulins

Indications & Dose:

Prevention of development of AntiD antibodies in Rh negative mothers after child birth, abortion beyond 13 weeks gestation, antepartum prophylaxis at 26-28 weeks gestation. i/v application should be administered not later than 48 hours post partum and i/m application not later than 72 hours post-partum.

DOSE 

Adults

Antepartum Prophylaxis Adult: IM 1 vial at approximately 28 wk; followed by 1 vial within 72 h of delivery if infant is Rh-positive.

Postpartum Prophylaxis 

Adult: IM 1 vial within 72 h of delivery if infant is Rhpositive.

Following Amniocentesis, Miscarriage, Abortion,

Ectopic Pregnancy

Adult: IM 1 vial of the microdose, preferably within 3 h but at least within 72 h.

Transfusion Accident

Adult: IM 1 vial for each volume of RBCs infused divided by 15, given within at least 72 h of accident.

Children Not recommended.

Contraindications:

CONTRAINDICATION & PRECAUTIONS CONTRAINDICATED IN:

Rho (D)-positive or Dupositive patient; person previously immunized against Rho (D) factor, hypersensitivity for thimerosal (in commercial preparations), thrombocytopenia, or bleeding disorders.

Side Effects:

Cautions:

Precautions:

Interaction:

Drugs

May interfere with immune response to live virus vaccine; should delay use of live virus vaccine for 3 mo after administration of Rho (D) immune globulin. and typing. Confirm that mother is Rho (D) and Dunegative. Infant must be Rh-positive.

Warnings:

Adverse Effects:

Infrequent: injection site irritation, slight fever, myalgia, lethargy. 

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: