SUCRALFATE

Indications & Dose:

Benign gastric ulceration

 Benign duodenal ulceration

• BY MOUTH 

Child 15–17 years: 2 g twice daily, dose to be taken on rising and at bedtime, alternatively 1 g 4 times a day for 4–6 weeks, or in resistant cases up to 12 weeks, dose to be taken 1 hour before meals and at bedtime;maximum 8 g per day

Adult: 2 g twice daily, dose to be taken on rising and atbedtime, alternatively 1 g 4 times a day for 4–6 weeks,

or in resistant cases up to 12 weeks, dose to be taken 1 hour before meals and at bedtime; maximum 8 g per day

Chronic gastritis

• BY MOUTH

Adult: 2 g twice daily, dose to be taken on rising and atbedtime, alternatively 1 g 4 times a day for 4–6 weeks or in resistant cases up to 12 weeks, dose to be taken1 hour before meals and at bedtime; maximum 8 g per day

Prophylaxis of stress ulceration in child under intensive care 

• BY MOUTH

Child 15–17 years: 1 g 6 times a day; maximum 8 g per day continued

Prophylaxis of stress ulceration

• BY MOUTH

Adult: 1 g 6 times a day; maximum 8 g per day.

NOTE; Tablets may be dispersed in 10-15ml of water; antacids should not be taken half an hour before or after a dose.

Children: Doses of 40-80mg/kg/day divided every 6 hours

Contraindications:

Renal impairment

Side Effects:

CNS: Dizziness, drowsiness, headache, vertigo

Eye/ENT: Laryngospasm

GI: Constipation, diarrhea, dry mouth, gastric pain, indigestion, nausea, vomiting

SKIN: Pruritus, rash. urticaria

Cautions:

In pregnancy & breast-feeding

Precautions:

Renal failure, dialysis (small amounts aluminum absorbed with sucralfate)

Interaction:

Drugs

Ketoconazole: Reduces plasma levels of antifungal

Phenytoin: Modest reduction in GI absorption of phenytoln

Quinolones: Reduced antibiotic levels

Warfarin: Isolated cases of reduced hypoprothrombinemic response to warfarin

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: