Clinical Pharmacology Details


ESOMEPRAZOLE/ SODIUM BICARBONATE


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Indications & Dose:

INDICATIONS AND DOSE AND ADMINISTRATION


Adults: 


Active Dudenal Ulcer:


20mg/1100mg per day for 4-8 weeks.Active


GastricUlcer


40mg/1100mg per day for 4-8 weeks.


Symptomaic GRED:


 20mg/1100mg per day for 4 weeks.


Active Errosive esophagitis:  20mg/1100mg per day for 4-8 weeks.; maintanance healing ; 20/1100mg per day upto 12 months

Contraindications:

Hypersensitivity (anaphylaxis, anaphylacticshock, angioadema & urticaria)” to any components of the formulation.

Side Effects:

Cautions:

Precautions:

General: Symptomatic response to therapy with omeprazole does not preclude the presence of gastric malignancy. Atrophic gastritis hasbeen noted occasionally in gastric corpus biopsies from patients treated long-term with omeprazole.


Patients on Sodium restricted diet: Patients of sodium restricted diet or at risk of developing congestive heart failure (CHF) should be informed of the sodium content of Omeprazole + Sodium bi carbonate Sodium bicarbonate is contraindicated in patients with metabolic alkalosis and hypocalcemia.Sodium bicarbonate should be used with caution in patients with Barter’s J syndrome, hypokalemia, respiratory alkalosis, and problems with acid-1 base balance. Long-term administration of bicarbonate with c or milk can cause milk-alkali syndrome.

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: