MANNITOL 20%

Indications & Dose:

Cerebral oedema 

• BY INTRAVENOUS INFUSION

Adult: 0.25–2 g/kg, repeated if necessary, to be administered over 30-60 minutes, dose may be repeated 1–2 times after 4–8 hours

Contraindications:

Anuria .intracranial bleeding

(except during craniotomy) . severe cardiac failure . severe dehydration . severe pulmonary oedema

Side Effects:

 Uncommon Electrolyte imbalance fluid imbalance hypotension thrombophlebitis

Rare Anaphylaxis arrhythmia blurred vision chest pain .chills . convulsions cramp dehydration  dizziness dry mouth . fever . focal osmotic nephrosis . headache

hypersensitivity reactions . hypertension . nausea . oedema pulmonary oedema . raised intracranial pressure rhinitis .skin necrosis thirst urinary retention . urticaria . vomiting

Very rare Acute renal failure congestive heart failure

PREGNANCY Manufacturer advises avoid unless essential—no information available.

BREAST FEEDING Manufacturer advises avoid unless essential—no information available.

RENAL IMPAIRMENT Use with caution in severe impairment.

PRE-TREATMENT SCREENING Assess cardiac function before treatment.

MONITORING REQUIREMENTS Monitor fluid and electrolyte balance, serum osmolality, and cardiac, pulmonary and renal function.

DIRECTIONS FOR ADMINISTRATION For mannitol 20%, an in-line filter is recommended (15- micron filters have been used).

Cautions:

Extravasation causes inflammation and thrombophlebitis

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: