NORADRENALINE/ NOREPINEPHRINE

Indications & Dose:

Acute hypotension

• BY INTRAVENOUS INFUSION

Adult: Initially 0.16–0.33 mL/minute, adjusted according to response, to be given via central venous catheter, of a solution containing noradrenaline 40 micrograms(base)/mL

DOSE EQUIVALENCE AND CONVERSION

1 mg of noradrenaline base is equivalent to 2mg of noradrenaline acid tartrate. Doses expressed as the base

Contraindications:

Hypertension

Side Effects:

Cautions:

Coronary vascular thrombosis . diabetes mellitus . elderly . extravasation at injection site may cause necrosis . following myocardial infarction . hypercapnia . hyperthyroidism . hypoxia . mesenteric vascular thrombosis . peripheral vascular thrombosis . Prinzmetal’s variant angina . uncorrected hypovolaemia

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Frequency not defined.

Cardiovascular: Bradycardia, arrhythmia, peripheral (digital) ischemia

Central nervous system: Headache (transient), anxiety

Local: Skin necrosis (with extravasation)

Respiratory: Dyspnea, respiratory difficulty

PREGNANCY Avoid—may reduce placental perfusion.

MONITORING REQUIREMENTS Monitor blood pressure and rate of flow frequently 

DRUG INTERACTIONS

Avoid Concomitant Use

Avoid concomitant use of Norepinephrine with any of the following: lobenguane

Increased Effect/Toxicity

Norepinephrine may increase the levels/effects of

Bromocriptine; Sympathomimetics

The levels/effects of Norepinephrine may be increased by: Antacids; Beta-Blockers; Cannabinoids; Carbonic Anhydrase Inhibitors; COMT Inhibitors; MAO Inhibitors; Serotonin/ Norepinephrine Reuptake Inhibitors; Tricyclic Antidepressants.

Patient And Carer Advice: