Indications & Dose:
Schizophrenia Combination therapy for mania
Adult: 10 mg daily, adjusted according to response, usual dose 5–20 mg daily, doses greater than 10mg daily only after reassessment, when one or more factors present that might result in slower metabolism (e.g. female gender, elderly, non-smoker) consider lower initial dose and more gradual dose increase; maximum 20 mg per day
Preventing recurrence in bipolar disorder
Adult: 10 mg daily, adjusted according to response, usual dose 5–20 mg daily, doses greater than 10mg daily only after reassessment, when one or more factors present that might result in slower metabolism (e.g. female gender, elderly, nonsmoker) consider lower initial dose and more gradual dose increase; maximum 20 mg per day
Monotherapy for mania
Adult: 15 mg daily, adjusted according to response, usual dose 5–20 mg daily, doses greater than 15mg daily only after reassessment, when one or more factors present that might result in slower metabolism (e.g. female gender, elderly, non-smoker) consider lower initial dose and more gradual dose increase; maximum 20 mg per day
Control of agitation and disturbed behaviour in schizophrenia or mania
Adult: Initially 5–10 mg for 1 dose; usual dose 10 mg for 1 dose, followed by 5–10 mg after 2 hours if required, maximum 3 injections daily for 3 days; maximum daily combined oral and parenteral dose 20 mg, when one or more factors present that might result in slower metabolism (e.g. female gender, elderly, non-smoker) consider lower initial dose and more gradual dose increase
Elderly: Initially 2.5–5 mg, followed by 2.5–5 mg after 2 hours if required, maximum 3 injections daily for 3 days; maximum daily combined oral and parenteral dose 20 mg, when one or more factors present that might result in slower metabolism (e.g. female gender, elderly, non-smoker) consider lower initial dose and more gradual dose increase
Contraindications:
Side Effects:
Cautions:
Precautions:
hepatic function impairment; children < 18 yr; history of myocardial infarction, heart failure, cardiac conduction abnormalities; cerebrovascular disease; seizure disorders; patients at risk for aspiration pneumonia; prostatic hypertrophy, narrow-angle glaucoma, history of paralytic ileus
Interaction:
Drugs
Carbamazepine: Decreased olanzapine concentrations
Levodopa: Antagonism of the effects of levodopa due to dopamine receptor blockade
Warnings:
Adverse Effects:
Lactations:
Excretion into human breast milk unknown; excreted in the milk of treated rats
Special Precautions:
Counselling:
Side Effects Or Adverse Reactions:
CNS: Agitation, akathisia, amnesia. anxiety, articulation impairment, dizziness, euphoria, headache, hostility, hypertonia, insomnia, nervousness, sommolence, stuttering, tardive dyskinesia, tremor
CV: Chest pain, edema; hypotension, postural hypotension, tachycardia
EENT: Amblyopia, blepharitis, pharyngitis, rhinitis
GI: Abdominal pain, constipation, dry mouth, increased appetite, transaminase elevations
GU: Premenstrual syndrome
METAB: Weight gain
MS: Back pain, joint pain, twitching
SKIN: Rash
MISC: Fever neuroleptic malignant syndrome
Patient And Carer Advice:
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