Ticagrelor

Indications & Dose:

In combination with aspirin for the prevention of atherothrombotic events in patients with acute coronary syndrome

BY MOUTH

Adult: Initially 180 mg for 1 dose, then 90 mg twice daily usually for up to 12 months Alternative to clopidogrel in patients undergoing

percutaneous coronary intervention 

BY MOUTH

Adult: 180 mg, as a single dose

Contraindications:

Active bleeding . history of intracranial haemorrhage

Side Effects:

Common or very common Bruising . dyspnoea . haemorrhage Uncommon Abdominal pain . diarrhoea . dizziness . dyspepsia . gastritis . headache . nausea . pruritus . rash . vomiting Rare Confusion . constipation . hyperuricaemia . paraesthesia . raised serum creatinine . vertigo 

PREGNANCY Manufacturer advises avoid—toxicity in  animal studies.

BREAST FEEDING Manufacturer advises avoid— present in milk in animal studies.

HEPATIC IMPAIRMENT Avoid in moderate or severe impairment—no information available.

Cautions:

Asthma . bradycardia (unless pacemaker fitted) . chronic obstructive pulmonary disease . discontinue 7 days before elective surgery if antiplatelet effect not desirable . history of hyperuricaemia . patients at increased risk of bleeding (e.g. from recent trauma, surgery, gastrointestinal bleeding, or coagulation disorders) . second- or third-degree AV block (unless pacemaker fitted) . sick sinus syndrome (unless pacemaker fitted)

Precautions:

Interaction:

 Caution with concomitant use of drugs that increase risk of bleeding.

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: