Sodium Bicarbonate

Indications & Dose:

INDICATIONS AND DOSE: Antacid

• B Y MOUTH

Adult

• Antacid: Oral: Powder/Susp. One-½ tsf in a glass

of water every 2 hour, max: 4tsf daily.

• Antacid: 520 mg; may repeat in 30 min

Contraindications:

Side Effects:

CNS: Confusion; headache, hyperreflexia, irritability,

seizures caused by alkalosis, stimulation, tetany,

tremors, twitching, weakness

CV: Cardiac arrest, edema, irregular pulse, water

retention, weight gain

G1: Acid rebound, belching, cramps, distension,

flatulence, increased thirst, paralytic ileus

GU: Calculi

METAB: Alkalosis, hypercalcemia or milk-alkali

syndrome, hypokalemia

RESP: Apnea, cyanosis, shallow, slow respirations

Cautions:

Precautions:

CHF, cirrhosis, hypertension, hypocalcemia, toxemia, renal disease

Interaction:

Drugs

Amphetamines: Sodium bicarbonate inhibits the elimination and increases the effects of amphetamines

Beta blockers: Reduced absorption

Cefpodoxime: Reduced absorption

Cefuroxime: Reduced serum levels with reduced antibiotic efficacy

Ephedrine: Large doses of sodium bicarbonate increase theserum concentrations of ephedrine

Flecainide: Increased urine pH will increase flecainide serum concentration

Glipizide: Enhanced rate of glipizide absorption

Glyburide: Enhanced rate of glyburide absorption

Iron: Reduced absorption

Ketoconazole: Decreased absorption

Lithium: Sodium bicarbonate may lower lithium plasma concentrations

Methenamine compound: Sodium bicarbonateinduced urinary pH changes interfere with antibacterial activity of methenamine compounds

Mexiletine: Increased urine pH increases mexiletine concentrations

Pseudoephedrine: Sodium bicarbonate-induced urinary pH changes may markedly inhibit the elimination of pseudoephedrine

Quinidine: Sodium bicarbonate-induced urinary pH changes may increase quinidine concentrations

Quinotones: Reduced absorption

Salicylates: Sodium bicarbonated-induced urinary pH changes can decrease serum salicylate concentrations

Tetracyclines: Reduced absorption

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: