Vortioxetine

Indications & Dose:

Major depression

BY MOUTH

Adult: Initially 10 mg once daily; adjusted according to response to 5–20 mg once daily

Elderly: Initially 5 mg once daily; increased if necessary up to 20 mg once daily

Contraindications:

Side Effects:

Common or very common Abnormal dreams . constipation . diarrhoea . dizziness . nausea . pruritus . vomiting Uncommon Flushing . night sweats Rare Bleeding disorders

Frequency not known Neuroleptic malignant syndrome— discontinue (potentially fatal) . serotonin syndrome . sexual dysfunction (with 20mg dose only)

Cautions:

CAUTIONS Bleeding disorders . cirrhosis of the liver (risk of hyponatraemia) . elderly (risk of hyponatraemia) . history of mania (discontinue if patient entering manic phase) . history of seizures . unstable epilepsy

CAUTIONS, FURTHER INFORMATION

Seizures Discontinue treatment in patients who develop seizures or if there is an increase in seizure frequency.

Elderly Manufacturer advises caution when treating elderly patients with doses over 10 mg daily—limited information.

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

PREGNANCY Manufacturer advises avoid unless potential benefit outweighs risk—toxicity in animal studies. If used  during the later stages of pregnancy, there is a risk of neonatal withdrawal symptoms and persistent pulmonary hypertension in the newborn.

BREAST FEEDING Manufacturer advises avoid—present in milk in animal studies.

HEPATIC IMPAIRMENT Manufacturer advises caution in severe impairment—no information available.

RENAL IMPAIRMENT Manufacturer advises caution in severe impairment—limited information available.

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: