Misoprostol

Indications & Dose:

Benign gastric and duodenal operation and NSAID associated ulceration.:

• BY MOUTH

Adult: 800 mcg daily in 2-4 divided doses with breakfast or main meals and at bedtime: treatment should be continued for at least 4 weeks and may be continued for up to 8 weeks if required.

Prophylaxis of NSAID-induced gastric and duodenal ulcer.

• BY MOUTH

Adults: 200 mcg 4 times daily (if not tolerated, reduced to 200 micrograms 2-3 times daily, but less effective).

Children: Not recommended.

Contraindications:

Women of childbearing age.

Side Effects:

Cautions:

Precautions:

Conditions where hypotension might precipitate severe complications (e.g. cerebrovascular disease, cardiovascular disease). 

Interaction:

Antacids

Warnings:

Adverse Effects:

Diarrhoea (may occasionally be severe and require withdrawal, reduced by giving single doses not exceeding 200 mcg and by avoiding magnesium-containing antacids); abdominal pain, dyspepsia, flatulence, nausea and vomiting, abnormal vaginal bleeding (including intermenstrual bleeding, menorrhagia, and postmenopausal bleeding), rashes, dizziness.

Increased Effect/Toxicity Misoprostol may increase the levels/effects of: Oxytocin

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: