Lopinavir+ritonavir

Indications & Dose:

HIV infection in combination with other antiretroviral drugs

BY MOUTH USING TABLETS

Adult: 400/100 mg twice daily, alternatively 800/200 mg once daily, once daily dose to be used only

in adults with a HIV strain that has less than 3 mutations to protease inhibitors BY MOUTH USING ORAL SOLUTION

Adult: 5 mL twice daily, to be taken with food, oral solution contains 400mg lopinavir, 100mg ritonavir/5mL

Contraindications:

Side Effects:

Common or very commonAmenorrhoea . anxiety . arthralgia . colitis . hypertension . menorrhagia . neuropathy . night sweats . sexual dysfunction . weight

changes UncommonAbnormal dreams . alopecia .AV block . cerebrovascular accident . convulsions . deep vein thrombosis . dry mouth . gastro-intestinal ulcer .

haematuria . myocardial infarction . nephritis . rectal bleeding . stomatitis . tinnitus . tremor . visual disturbances

Cautions:

Cardiac conduction disorders . pancreatitis . patients at high risk of cardiovascular disease (especially if 10-year cardiovascular risk greater than 20%) . structural heart disease

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Avoid oral solution due to high propylene glycol content; use tablets only if potential benefit outweighs risk (toxicity in animal studies).

Avoid oral solution due to propylene glycol content; manufacturer advises avoid tablets in severe impairment.

Avoid oral solution due to high propylene glycol content. Use tablets with caution in severe impairment.

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: