Agomelatine

Indications & Dose:

Major depression

BY MOUTH

Adult: 25 mg daily, dose to be taken at bedtime, dose to be increased if necessary after 2 weeks, increased if necessary to 50 mg daily, dose to

be taken at bedtime

DOSE ADJUSTMENTS DUE TO 

f smoking started or stopped during treatment.

Contraindications:

Dementia .patients over 75 years of age

Side Effects:

Common or very common Abdominal pain .agitation .anxiety .back pain . constipation .diarrhoea .dizziness .drowsiness .fatigue .headache

.increased serum transaminases .nausea .sleep disturbances . sweating .vomiting Uncommon Blurred vision .eczema .paraesthesia .restless legs

syndrome . tinnitus Rare Hepatic failure . hepatic injury . hepatitis .rash . weight changes Frequency not knownPruritus .suicidalbehaviour.

Cautions:

Bipolar disorder .diabetes .excessive alcohol consumption . hypomania .mania .non-alcoholic fatty liver disease . obesity

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

PREGNANCY Manufacturer advises avoid.

BREAST FEEDING Avoid—present in milk in animal studies.

HEPATIC IMPAIRMENT Avoid. Do not start if serum transaminases exceed 3 times the upper limit of reference range.

RENAL IMPAIRMENT Caution in moderate to severe impairment.

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: