Caspofungin acetate

Indications & Dose:

Invasive aspergillosis | Invasive candidiasis | Empirical treatment of systemic fungal infections in patients with neutropenia

BY INTRAVENOUS INFUSION

Adult (body-weight up to 81 kg): 70 mg once daily for 1 day then 50 mg once daily

Adult (body-weight 81 kg and above): 70 mg once daily

Contraindications:

-

Side Effects:

Common or very common Arthralgia . diarrhoea . dyspnoea . headache . hypokalaemia . injection-site reactions . nausea . pruritus .rash . sweating . vomiting

Uncommon Abdominal pain . anaemia . anorexia . anxiety . arrhythmia . ascites . blurred vision . bronchospasm . chest pain . cholestasis . constipation . cough . disorientation . dizziness . dry mouth . dyspepsia . dysphagia . erythema multiforme . fatigue . flatulence . flushing . heart failure . hepatic dysfunction . hyperglycaemia . hypertension . hypoaesthesia . hypocalcaemia . hypomagnesaemia . hypotension . leucopenia . metabolic acidosis . muscular weakness . myalgia . palpitation . paraesthesia .renal failure . sleep disturbances .taste disturbances . thrombocytopenia .thrombophlebitis .tremor

HEPATIC IMPAIRMENT 70 mg on first day then 35 mg once daily in moderate impairment. No information available for severe impairment.

DIRECTIONS FOR ADMINISTRATION For intravenous infusion give intermittently in Sodium chloride 0.9%.

Allow vial to reach room temperature initially reconstitute each vial with 10.5 mL water for injections mixing gently to dissolve then dilute requisite dose in 250 mL infusion fluid (35- or 50-mg doses may be diluted in 100 ml infusion fluid if necessary) give over 60 minutes incompatible with glucose solutions.

Cautions:

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Precautions:

-

Interaction:

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Warnings:

-

Adverse Effects:

-

Lactations:

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Special Precautions:

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Counselling:

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Side Effects Or Adverse Reactions:

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Patient And Carer Advice:

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