Bendamustine hydrochloride

Indications & Dose:

Treatment of chronic lymphocytic leukaemia | Treatment of non-Hodgkins lymphoma | Treatment of multiple myeloma

BY INTRAVENOUS INFUSION

Adult: (consult local protocol)

Contraindications:

Jaundice . low leucocyte count. low platelet count. major surgery less than 30 days before start of treatment. severe bone marrow suppression

Side Effects:

Common or very common Amenorrhoea . angina . anorexia . arrhythmias . chills . constipation . dehydration . diarrhoea . electrolyte disturbances . haemorrhage . hypertension . hypokalaemia . hypotension . infection . insomnia . malaise . pain . palpitation . pyrexia .respiratory dysfunction

Uncommon Pericardial effusion Rare Acute circulatory failure . drowsiness . sweating . voice changes

Very rare Anticholinergic syndrome . ataxia . cardiac failure . encephalitis . haemolysis . multiple organ failure . myocardial infarction . neurological disorders . paraesthesia . peripheral neuropathy . phlebitis . pulmonary fibrosis .tachycardia .taste disturbance

Frequency not known Alopecia . bone-marrow suppression . extravasation . hyperuricaemia . male sterility . nausea . oral mucositis . premature menopause . secondary malignancy . Stevens-Johnson syndrome . thromboembolism .toxic epidermal necrolysis .tumour lysis syndrome . vomiting

Secondary malignancy Prolonged use of alkylating drugs particularly when combined with extensive irradiation is associated with a marked increase in the incidence of acutenon-lymphocytic leukaemia.

Cautions:

Avoid in acute porphyrias : cardiac disorders-monitor serum potassium and ECG

Precautions:

-

Interaction:

-

Warnings:

Effective contraception is required during treatment in men or women and for 6 months after treatment in men. See also Pregnancy and reproductive function in Cytotoxic drugs

PREGNANCY Avoid

BREAST FEEDING Discontinue breast-feeding.

HEPATIC IMPAIRMENT Consider a 30% dose reduction in moderate impairment. Avoid in severe impairment.

RENAL IMPAIRMENT No information available on use in patients with creatinine clearance less than 10 mL/minute.

ANTINEOPLASTIC DRUGS ANTI-ANDROGENS

Adverse Effects:

-

Lactations:

-

Special Precautions:

-

Counselling:

-

Side Effects Or Adverse Reactions:

-

Patient And Carer Advice: