Pethidine hydrochloride (Meperidine)

Indications & Dose:

Acute pain

BY MOUTH

Adult: 50-150 mg every 4 hours

BY SUBCUTANEOUS INJECTION OR BY INTRAMUSCULAR INJECTION

Adult: 25-100 mg then 25-100 mg after 4 hours for debilitated patients use dose described for elderly patients

Elderly: Initially 25 mg then 25-100 mg after 4 hours

BY SLOW INTRAVENOUS INJECTION

Adult: 25-50 mg then 25-50 mg after 4 hours for debilitated patients use dose described for elderly patients

Elderly: Initially 25 mg then 25-50 mg after 4 hours Obstetric analgesia

BY SUBCUTANEOUS INJECTION OR BY INTRAMUSCULAR INJECTION

Adult: 50-100 mg then 50-100 mg after 1-3 hours if required maximum 400 mg per day

Premedication

BY INTRAMUSCULAR INJECTION

Adult: 25-100 mg dose to be given 1 hour before operation for debilitated patients use dose described for elderly patients

Elderly: 25 mg dose to be given 1 hour before operation

BY SUBCUTANEOUS INJECTION OR BY INTRAMUSCULAR INJECTION

Adult: 25-100 mg every 2-3 hours if required for debilitated patients use dose described for elderly patients

Elderly: Initially 25 mg every 2-3 hours if required

Contraindications:

Phaeochromocytoma

Side Effects:

Hypothermia .restlessness .tremor Overdose Convulsions reported in overdosage.

BREAST FEEDING Present in milk but not known to be harmful.

RENAL IMPAIRMENT Avoid use or reduce dose opioid effects increased and prolonged and increased cerebral sensitivity occurs.

Cautions:

Accumulation of metabolites may result in neurotoxicity . cardiac arrhythmias . not suitable for severe continuing pain . severe cor pulmonale

Precautions:

-

Interaction:

-

Warnings:

-

Adverse Effects:

-

Lactations:

-

Special Precautions:

-

Counselling:

-

Side Effects Or Adverse Reactions:

-

Patient And Carer Advice:

-