Tofacitinib

Indications & Dose:

Treatment of adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate. It may be used as monotherapy or in combination with  methotrexate or other nonbiologic disease-modifying antirheumatic drugs (DMARDs).

DOSAGE 

Rheumatoid Arthritis

Psoriatic Arthritis (in combination with nonbiologic DMARDs)

ORALLY

Adult.5 mg twice daily or 11 mg once daily. 

Ulcerative Colitis

10 mg twice daily for at least 8 weeks. then 5 or 10 mg twice daily. Discontinue after 16 weeks of 10 mg twice daily, if adequate therapeutic benefit is not achieved. Use the lowest effective dose to

maintain response. 

Contraindications:

None  

Side Effects:

Cautions:

Precautions:

Serious Infections. Avoid

Gastrointestinal Perforations. Use with caution in patients that may be at increased risk.

Interaction:

Warnings:

Adverse Effects:

Most common adverse reactions are:

Rheumatoid and Psoriatic Arthritis, monotherapy or in combination with DMARDs. upper respiratory tract infection, nasopharyngitis, diarrhea, and headache.  

Ulcerative Colitis. nasopharyngitis, elevated cholesterol levels, headache, upper respiratory tract infection, increased blood creatine phosphokinase, rash, diarrhea,and herpes zoster. 

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: