| ID | 400 |
|---|---|
| Name | CHRONIC MUCOCUTANEOUS CANDIDIASIS |
| Cause | Candida spp., mainly Candida albicans. CMC is an infectious phenotype in patients with inherited or acquired T-cell deficiency |
| Signs Symptoms | Symptoms and Signs of Chronic Mucocutaneous Candidiasis Nails may be thickened, cracked, and discolored, with edema and erythema of the surrounding periungual tissue, resembling clubbing. Skin lesions are crusted, pustular, erythematous, and hyperkeratotic. Scalp lesions may result in scarring alopecia |
| Diagnosis | Diagnosis of chronic mucocutaneous candidiasis is based on the presence of recurrent candidal skin or mucosal lesions when no other known causes of candidal infection (eg, diabetes, antibiotic use) are present. Patients are screened for endocrine disorders based on clinical suspicion. |
| Investigations | Diagnosis of chronic mucocutaneous candidiasis is based on the presence of recurrent candidal skin or mucosal lesions when no other known causes of candidal infection (eg, diabetes, antibiotic use) are present. Patients are screened for endocrine disorders based on clinical suspicion. |
| Management | Topical antifungal agents. Azole antifungal cream (e.g., bifonazole, ketoconazole, neticonazole hydrochloride, lanoconazole and luliconazole) is most effective. Terbinafine hydrochloride and amorolfine hydrochloride |
| Introduction | Chronic mucocutaneous candidiasis (CMCC) is a heterogeneous group of syndromes with the common features of chronic noninvasive Candida infections of the skin, nails, and mucous membranes that are usually resistant to topic treatment and absence of invasive fungal infections. |
| History | |
| Etiology | Chronic mucocutaneous candidiasis (CMCC) is a heterogeneous group of syndromes with the common features of chronic noninvasive Candida infections of the skin, nails, and mucous membranes that are usually resistant to topic treatment and absence of invasive fungal infections. |
| Clinical Features | Nails may be thickened, cracked, and discolored, with edema and erythema of the surrounding periungual tissue, resembling clubbing. Skin lesions are crusted, pustular, erythematous, and hyperkeratotic. Scalp lesions may result in scarring alopecia. |
| Preventions | |
| Treatment | Therapy for cutaneous candidiasis is dominated by topical antifungal agents. antifungal cream (e.g., bifonazole, ketoconazole, neticonazole hydrochloride, lanoconazole and luliconazole) is most effective. Terbinafine hydrochloride and amorolfine hydrochloride are also useful. |
| Complications | A variety of disorders including endocrine dysfunctions, alopecia, vitiligo, malabsorption syndromes, neoplasms and other infections may also occur in patients with chronic mucocutaneous candidiasis, but these vary considerably from patient to patient |
| Prognosis | Life expectancy is generally normal but significant morbidity is associated with the chronic nail and mucocutaneous infections and associated endocrine and/or autoimmune disease. In rare cases, premature death occurs secondary to disseminated Candida infection, sepsis, pneumonia, or mycotic aneurysms |
| Types | |
| Classification | Chronic mucocutaneous candidiasis (CMCC) is a heterogeneous group of syndromes with the common features of chronic noninvasive Candida infections of the skin, nails, and mucous membranes that are usually resistant to topic treatment and absence of invasive fungal infections. |
| Observation | |
| Pathology |
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