Indications & Dose:

Acute leukaemias, lymphomas and certain other malignant conditions, neuroblastoma. Wilms tumour; Other: Idiopathic thrombocytopenic purpura. 
DOSE
Adults Administered i/v only. 1-2 mg/m2 /week i.v with a duration of therapy ranging from 4-8 weeks.
Children 2 mg/m2 i/v at weekly inter-vascular as a single dose. 

Contraindications:

Pregnancy. Hypersensitivity to vincristine and other related agent. Intrathecal administration, demyelinating Charcot Marie Tooth Syndrome

Cautions:

Acute uric acid, nephropathy, hepatic & renal impairment.

Precautions:

Infection, neuromuscular disease, leucopenia, pulmonary disorders, leukaemia, radiation therapy, extravasation, concomitant neurotoxic drugs. Eye contact, concurrent vaccination.
Breast-feeding: & old age: Use with caution. 

Interaction:

Drugs
Digoxin: Decreased plasma digoxin levels and renal excretion.

L-asparaginase:

Hepatic clearance of vincristine is reduced if Lasparaginase is administered first. Thus to minimise toxicity, vincristine should be given 12 to 24 hours before administering L-asperaginase

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: