Indications & Dose:

Acute lymphocytic leukaemia, hypoglycaemia due to hypersensitivity associated with pancreatic is let tumours (insulinomas). Malignant lymphoma,acute leukaemia.
DOSE
Adults

Acute lymphocytic leukemia: 200 IU/kg daily i/v for 28 days. Insuli-nomas: 20.000 IU given daily via hepatic artery for 7-10 days.

Paediatrics

Acute hymphocytic leukemia same as adult for i/ v.For i/m, 6000 iu/m body surface area.
Three times a week alone or in combination with vincristine and prednisone

Contraindications:

Chicken pox, herpes zooster. Anaphylactic reaction to L-asparaginae, history of pancreatitis or if pancreatitis is present

Cautions:

Diabetes mellitus, goitre, gout, hepatic function impairment, infection, previous exposure to cytotoxic drugs or radiation therapy.

Precautions:

Hypersensitivity.

Pregnancy: Use only if potential benefit justifies risk to the foetus.
Breast-feeding: Discontinue nursing or the drug.
Old age: Use with caution. 

Interaction:

Drugs

Vincristine and Prednisone: Associated with increased toxicity.
Methotrexate: Effect on malignant cells diminished or abolished as long as plasma asparginase levels are suppressed.
Cytarabine: Synergistic effect.

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: