Indications & Dose:

Treatment of pregnancy-associated nausea and vomiting
BY MOUTH
Oral:
Adults: Two tablets (a total of Doxyiamine 20 mg and Pyridoxine 20 mg) at bedtime; in severe cases or in cases with nausea/vomitingduring the day, dosage may be increased by 1 tablet in the morning and/or afternoon

Dosage adjustment in renal impairment: No dosage adjustment required.

Contraindications:

Hypersensitivity to Doxyiamine, Pyridoxine, or any component of the formulation

Cautions:

Precautions:

Interaction:

Anticholinergic agents: Central and/or peripheral anticholinergic syndrome can occur when administered with narcotic analgesics, phenothiazines and other antipsychotics (especially with high anticholinergic activity), tricyclic antidepressants, quinidine and some other antiarrhythmics, and antihistamines. Cholinergic agents: Drugs with high anticholinergic activity may antagonize the therapeutic effect of cholinergic agents; includes donepezil, rivastigmine, and tacrine. CNS depressants: Sedative effects may be additive with CNS depressants; includes ethanol, benzodiazepines, barbiturates, narcotic analgesics, and other sedative agents; monitor for increased effect.

ETHANOL/NUTRITION/HERB INTERACTIONS:

Ethanol: Avoid ethanol (may increase CNS depression).

Herb/Nutraceutical: Avoid valerian, St John’s wort, kava kava, gotu kola (may increase CNS depression).

Warnings:

May cause drowsiness; patient should avoid tasks requiring alertness (eg, driving, operating machinery) until effects are known. Sedative effects of CNS depressants or ethanol are potentiated. Use with caution in patients with angle-closure glaucoma ,pyloroduodenal obstruction (including stenotic peptic ulcer), urinary tract obstruction (including bladder neck obstruction and symptomatic prostatic hyperplasia), hyperthyroidism, increased intraocular pressure, and cardiovascular disease (including hypertension and tachycardia).

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Cardiovascular: Palpitations, tachycardiaCentral nervous
system: Dizziness, disorientation, drowsiness, headache, paradoxical CNS stimulation, vertigo
Gastrointestinal: Anorexia, dry mucous membranes, diarrhea, constipation, epigastric pain, xerostomia
Genitourinary: Dysuria, urinary retention
Ocular: Blurred vision, diplopia

Patient And Carer Advice: