Indications & Dose:

INDICATIONS: With cyclosporin and corticosteroids for prophylaxis of acute rejection in allogeneic renal, cardiac or hepatic transplants.

DOSAGE:

ADULTS:

Renal transplants: 1gm twice daily starting within 72 hours of transplant.

Cardiac transplants: 1.5gm twice daily starting within 5 days of transplant.

Hepatic transplants: 1.5gm twice daily following intravenous therapy.

CHILDREN:

Renal transplants: Under 2 years not recommended; 2-18 years, 600mg/m2 twice daily, upto maximum 2gm daily

Contraindications:

Pregnancy, lactation

Cautions:

Precautions:

Monitor full blood counts regularly. GI disease, hereditary HGPRT deficiency, Elderly

Interaction:

Aciclovir, valaciclovir, ganciclovir, antacids, azathioprine, cholestyramine, probenecid, vaccines, tacrolimus.

Warnings:

Adverse Effects:

GI upset, blood dyscrasis, infections, hypertension, metabolic and CNS disturbances, respiratory disorders, colitis, pancreatitis, intestinal villous atrophy

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: