Indications & Dose:

INDICATIONS AND DOSE:

Chronic Hepatitis CAdults with chronic hepatitis C virus (HCV) infectiongenotypes 1, 2, 3, 4, 5, and 6

• BY MOUTH

1 tablet (400 mg sofosbuvir/ 100 mg velpatasvir) PO qDay

Treatment duration

Patients without cirrhosis or with compensated cirrhosis (Child-Pugh A): Sofosbuvir/velpatasvir for 12 weeks Patients with decompensated cirrhosis (Child-Pugh B or C): Sofosbuvir/velpatasvir plus weight-based ribavirin with food for 12 weeks The above regimens also apply to patients coinfected with HIV-1 Weight-based ribavirin dose <75 kg: 1000 mg/day PO divided BID =75 kg: 1200 mg/day PO divided BID Ribavirin starting dose and on-treatment dosage should be modified based on hemoglobin and creatinine clearance

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