Indications & Dose:

Neuromuscular blockade (intermediate duration) during surgery and intubation

INITIALLY BY INTRAVENOUS INJECTION

▶ Adult: Initially 150 micrograms/kg, then (by intravenous injection) maintenance 30 micrograms/kg every 20 minutes, alternatively (by intravenous infusion) initially 180 micrograms/kg/hour, then (by intravenous infusion) maintenance 60–120 micrograms/kg/hour, maintenance dose administered after stabilisation Neuromuscular blockade (intermediate duration) during intensive care

INITIALLY BY INTRAVENOUS INJECTION

▶ Adult: Initially 150 micrograms/kg, initial dose is optional, then (by intravenous infusion) 180 micrograms/kg/hour, adjusted according to response; (by intravenous infusion) usual dose 30–600 micrograms/kg/hour

DOSES AT EXTREMES OF BODY-WEIGHT

To avoid excessive dosage in obese patients, dose should be calculated on the basis of ideal body-weight.

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