| Product | Precaution | Interaction | Onset | Severity |
|---|---|---|---|---|
| CODEINE | Concurrent use of ETHANOL and CODEINE may result in increased sedation. | ETHANOL | Rapid (within 24 hours) | Moderate (mayexacerbate patient’s condition) |
| CODEINE | Concurrent use of CODEINE and TOBACCO may result in decreased pain tolerance. | TOBACCO | Rapid (within 24 hours) | Minor (little if any clinical effect) |
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