Scleroderma

Alternate Name: Progressive Systemic Sclerosis

Test:

S.ANA (+), S.ENA (+), ESR (H), Hb (L), S.iron.(L), S.vit. B. (L), B.LE cells (+), S.creatinine (N or' H in advanced disease), S.folic acid (L), S.gamma-globulin (H), U.protein (+ with renal in­volvement), &rheumatoid factor (+)

Sign:

Skin thickening, hypertension, telangiectasia

Dd:

Rheumatoid arthritis, SLE, Raynaud's pher1Ome-non, polycythaemia vera, progeria, myxoedema, porphyria cutanea tarda, lichen sclerosis, Werner's syn., pulnItitittlyifibrasis, amyloidosis, porphyria, other autOimmune diseases, malab­sorption syndromes, all causes of dysphagia

Phys:

Autoimmune disease of blood vessels and con­nective tissue causing organ fibrosis and vascular insufficiency