Sickle Cell Disease/Anaemia

Alternate Name:

Test:

Hb (L), blood film (AB ±target cells), specific PCR(+), reticulocyte count (VH), tissue DNA probe (+), S.iron (N or 11), S.LDH (H), 'Cr red cell survival (L), S.bilirubin (H), sodium metabisulfite screen­ing test (+)

Sign:

ChronicScleral icterus, asthenia, normal spleen, black Af­rican descentAcuteAbdominal pain & rigidity, fever, bone pain, paral­ysis, convulsions

Dd:

Other haernoglobinopathies, TB, genitourinarytumours, rheumatic fever, acute abdominal surgi­cal conditions, sickle thalassaemia, HbF syn.

Phys:

Dominant hereditary disorder of patients of black African descent